Ošetřovatelské perspektivy 2022, 5(1):13-25 | DOI: 10.25142/osp.2022.002

METHODOLOGY OF A GROUP ANTIGENIC SCREENING FOR SARS-COV-2

Iveta Bryjová1, Radka Stonišová2, Daniela Nedvědová1
1 Ústav nelékařských zdravotnických studií, Fakulta veřejných politik v Opavě, Slezská univerzita v Opavě
2 Oddělení patologické anatomie, Slezská nemocnice v Opavě

Background: This paper is based  on  one  of  the  algorithms  of  collective  testing, the method of group screening, which we experimentally verify during mandatory screening using POC antigen tests in connection with the spread of COVID-19.

Aim: To verify the model and make recommendations for collective testing for qualitative determination of SARS-CoV-2 antigen detection by POC antigen tests in the context of  population-wide screening.

Methods: POC antigen test kits for the qualitative detection of SARS-CoV-2 viral nucleoprotein antigens from  direct  nasal,  nasopharyngeal,  or  oropharyngeal  swabs in a selected population using recommended testing and collective (group) testing methodologies.

Results and discussion: We compared the optimization of the size of the collectively tested group with the sensitivity of the POC test sets. This sensitivity is not sufficient for optimized size (around 10 samples) for an estimated prevalence between 1 % and 2 %, but even the size cut down by the test sensitivity (up to 5 samples) provides not negligible savings.

Conclusions: We propose a test protocol for collective testing of five-member groups, which, assuming a 1 % to 2 % prevalence, provide a material saving factor of 0,25–0.3.

Keywords: Antigen test, sensitivity, specificity, screening, group testing, COVID-19, SARS-CoV-2

Received: November 17, 2021; Revised: December 19, 2021; Accepted: January 6, 2022; Published: June 9, 2022  Show citation

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Bryjová I, Stonišová R, Nedvědová D. METHODOLOGY OF A GROUP ANTIGENIC SCREENING FOR SARS-COV-2
. Ošetřovatelské perspektivy. 2022;5(1):13-25. doi: 10.25142/osp.2022.002.
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